propargyl peg3 alcohol

Propargyl-PEG3-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

L18I是一种专门靶向Btk的PROTAC，用于缓解自身免疫疾病中的炎症反应。此化合物包括三部分：靶蛋白配体IBT6A、连接器PROTAC Linker Propargyl-PEG3-alcohol，以及E3泛素连接酶配体Lenalidomide-Br。其靶蛋白配体的活性对照样品为IBT6A-CO-ethyne，而E3泛素连接酶配体与Linker的结合形态为Lenalidomide-C3-PEG3-N3。