procaspase-3

Duocarmycin A, an antitumor antibiotic, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results in HLC-2 cells typically apoptotic changes.

PAC-1 (Procaspase activating compound 1) 是一种 procaspase-3激活剂，诱导癌细胞凋亡，EC50为 2.08 μM，可用于研究淋巴瘤、黑色素瘤、实体瘤、乳腺癌和胸癌等治疗的试验。

17-Hydroxy sprengerinin C 是从黄精的根茎中分离得到的一种糖苷化合物，具有更强的抗癌活性。17-Hydroxy sprengerinin C 降低 Blc-2 和 pro-caspase3 的表达并增加 Bax 的产生。

CASP3 Activator 1541 是 caspase-3 酶原形式的激活剂，可诱导细胞死亡。

WF-210 is an effective activator of procaspase-3 that acts by inducing apoptosis in cancer cells and reducing tumor growth.

ZYZ-488 是一种凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂，抑制 procaspase-9 和 procaspase-3 激活，可用于研究心血管疾病。

MPT0B206 is a novel tubulin polymerization inhibitor. MPT0B206 induced G2/M cell cycle arrest and the appearance of the mitotic marker MPM-2 in K562 and K562R cells, which is associated with the upregulation of cyclin B1 and the dephosphorylation of Cdc2.