postsynaptic d2 receptor

lumateperone Tosylate (ITI-007) 是5-HT 2A 受体拮抗剂，Ki 为 0.54 nM，突触前 D2受体的部分激动剂和突触后 D2受体的拮抗剂，Ki 为 32 nM。

Lumateperone (ITI 722) 是一种 5HT2A 受体拮抗剂和多巴胺受体磷蛋白调节剂 (DPPM)。

Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.

OPC 4392 hydrochloride 作为突触前多巴胺受体 (dopamine receptor) 的激动剂以及突触后D2受体的拮抗剂，具有显著的生物活性。该化合物能有效逆转由Reserpine引起的多巴胺积累，并在Apomorphine诱导的小鼠模型中抑制刻板行为和攀爬行为。