pibrozelesin

Pibrozelesin is a water-soluble derivative of duocarmycin B2 that alkylates DNA by binding to adenine-thymine (A-T)-rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis.

Pibrozelesin hydrobromide 是 Carzelesin 的水解前药，具有抗癌活性。Carzelesin 是一种环丙基吡咯并吲哚前体分子，能够有效抑制肿瘤生长，可用于癌症研究。