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pf06463922

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  • 抑制剂&激动剂
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    TargetMol | Inhibitors_Agonists
  • Lorlatinib
    劳拉替尼, PF-6463922, PF-06463922, Loratinib
    T30611454846-35-5
    Lorlatinib (PF-6463922) 是一种具有口服活性，选择性，脑渗透性和 ATP 竞争性的ROS1 ALK 抑制剂，具有抗癌活性。它对 ROS1、野生型 ALK 和 ALKL1196M 的Ki 值分别为 <0.025 nM、<0.07 nM 和 0.7 nM。
    ApoptosisTyrosine KinasesROSROS KinaseALK
    • ¥ 253
    In stock
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  • PF-06463922 acetate
    T700601924207-18-0
    PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong activity against all known ALK and ROS1 mutants identified in patients with crizotinib-resistant disease. PF-06463922 is in clinical trials for the treatment of non–small cell lung cancer (NSCLC).
    Others
    • ¥ 17200
    10-14周
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