pep-2-avki acetate(1315378-69-8 free base)

pep2-AVKI acetate(1315378-69-8 free base) 选择性破坏 AMPA 受体亚基 GluA2（在 C 末端 PDZ 位点）与与 C 激酶 (PICK1) 相互作用的蛋白质结合的抑制剂肽。不影响 GluA2 与 GRIP 或 ABP 的结合，也不增加 AMPA 电流幅度或影响长期抑制 (LTD)。

pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).