pdgfrαd842v

Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret and is also a DNA repair suppressor through suppression of DNA repai

PDGFRαkinase inhibitor 3 (Compound L7) 是一种强效的PDGFRαD842V激酶抑制剂，其在生化分析和细胞分析中的IC50值分别为23.8 nM和2.1 nM。此化合物通过结合PDGFRαD842V的ATP结合位点，阻断下游信号通路，抑制激酶活性。PDGFRαkinase inhibitor 3 适用于胃肠道间质瘤 (GIST) 的研究。