pd 149163

PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.

SMTIN-P01 is a mitochondria-targeted Hsp90 inhibitor. It is made from the isopropyl amine of the Hsp90 inhibitor PU-H71 being replaced with the mitochondria-targeting moiety triphenylphosphonium.

PD-149163 hydrochloride 是一种神经降压素激动剂，具有抗精神病活性，可调节小鼠模型细菌内毒素脂多糖诱导的神经炎症，可用于研究神经系统疾病。