pc dbco-peg3-biotin

PC DBCO-PEG3-biotin is a trimeric polyethylene glycol (PEG) linker, specifically designed for antibody-drug conjugate (ADC) synthesis, with a cleavable moiety consisting of a dibenzocyclooctyne (DBCO) group and a biotin molecule. This linker provides a platform for the efficient attachment of drugs to antibodies, facilitating the targeted delivery and controlled release of therapeutic agents in ADCs[1].

PC Biotin-PEG3-azide 是一款可裂解（cleavable）的ADC连接子（linker），包含3个PEG单元，可用于抗体-活性分子偶联物（ADC）的合成。PC Biotin-PEG3-azide 属于点击化学试剂，其所带的叠氮（Azide）基团既能够与含炔基（Alkyne）的分子在铜催化下发生叠氮-炔环加成反应（CuAAc），也可与含DBCO或BCN基团的分子通过环张力驱动的炔-叠氮环加成反应（SPAAC）进行连接。