Paraherquamide E is a fungal metabolite originally isolated from P. charlesii with anthelmintic and insecticidal activities. It is lethal to C. elegans (LD50 = 6 μg ml). Paraherquamide E is also lethal to O. fasciatus (LD50 = 0.089 μg nymph). Oral administration of paraherquamide E (0.5-4 mg kg) reduces T. colubriformis fecal egg count in gerbils.