Larazotide is an octapeptide paracellularpermeability inhibitor whose structure is derived from a protein (zonula occludens toxin) secreted by Vibrio cholerae for treatment of Coeliac disease.
Secretin is an endocrine hormone that stimulates the secretion of bicarbonate-rich pancreatic fluids. Canine secretin can regulates gastric chief cell function and paracellularpermeability in canine gastric monolayers by a Src kinase-dependent pathway.