paclitaxel ceribate

Paclitaxel Ceribate is a mitotic inhibitor used in cancer chemotherapy.

Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。

DHA-paclitaxel, also know as Taxoprexin, is prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer.

Paclitaxel (Standard) 是 Paclitaxel 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。

Paclitaxel-d5 是 Paclitaxel 的氘代类似物。Paclitaxel 为最初从太平洋红豆杉树皮中分离得到的二萜类天然产物。Paclitaxel-d5 保留了母体化合物稳定微管并诱导有丝分裂阻滞从而触发细胞凋亡的能力，广泛用作分析检测中的内标物以及药物作用机制研究中的工具化合物。