osthole

Osthole (Osthol) 是一种天然抗组胺药替代试剂，可刺激成骨细胞增殖和分化。它可抑制组胺 H1受体活性，还可抑制细胞培养物中 HBV 的分泌。

2'E-3'-formaldehydylosthole 是一种天然化合物，可作为天然产物对照品，其 CAS 号为 73292-92-9。

AMPK-IN-5 (compound 7m) 是蛇床子素的衍生物，通过抑制JNK和p38的磷酸化以阻断MAPK信号通路，从而减少炎症细胞因子的释放。AMPK-IN-5 能有效降低葡聚糖硫酸钠诱导的溃疡性结肠炎和LPS诱导的急性肺损伤。

Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1].