Orexin B, human, is an endogenous agonist at Orexin receptors with Ki values of 420 nM for OX1 and 36 nM for OX2, respectively. Orexin B is a hypothalamic neuropeptide that stimulates food intake in rats.
Highly potent and selective OX2 receptor agonist; displays 400-fold selectivity over OX1 receptors. EC50 values are 0.13 and 52 nM for human OX2 and OX1 receptors respectively.