Olmesartanmedoxomil impurity C is an Olmesartanmedoxomil impurity. Olmesartanmedoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. [1]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [2]. Shah S, et al. Simultaneous Quantitative Analysis of OlmesartanMedoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4(2):88-94.
Tritylolmesartanmedoxomil is an intermediate in the synthesis of olmesartanmedoxomil , a prodrug form of the angiotensin II receptor 1 (AT1) antagonist olmesartan .1 1.Hanumantha Rao, B., Subramanyeswara Rao, I.V., Ravi Kanth, V., et al.A competent and commercially viable process for the synthesis of the anti-hypertensive drug olmesartanmedoxomilSci. Pharm.83(3)465-478(2015)
Olmesartan methyl ester is an intermediate in the synthesis of Olmesartanmedoxomil. Olmesartanmedoxomil is a potent and selective angiotensin AT1 receptor antagonist.