octadecanedioic acid

Octadecanedioic acid 是内源性代谢物的一种，是一种长链二羧酸，曾在雷氏综合征的血清游离脂肪酸中被发现。

Octadecanedioic acid-d32是Octadecanedioic acid的氘代标记版本。Octadecanedioic acid为内源性代谢物，可用于研究雷氏综合征。

9-Oxooctadecanedioic acid 是一种α,ω-二羧酸类脂肪单体，可以在Quercus suber的软木栓皮素中发现。9-Oxooctadecanedioic acid 在植物结构中起到重要作用。

Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner. |1. Callmann, C.E., Leguyader, C.L.M., Burton, S.T., et al. Antitumor activity of 1,18-octadecanedioic acid-paclitaxel complexed with human serum albumin. J. Am. Chem. Soc. 141(30), 11765-11769 (2019).

18-Oxooctadecanoic acid 是长链脂肪酸衍生物。该化合物经由 P450BM-3 特异性氧化，生成 α,ω-二羧酸 (1,18-十八烷二酸)，无需通过脱羧反应产生碳链缩短的烯烃。18-Oxooctadecanoic acid 可用于研究含醛基的长链脂肪酸代谢途径。