obtustatin

Highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitum

Obtustatin triacetate 是一种从 Vipera lebetina obtusa 毒液中提取的解整合素，是具有选择性的 α1β1 整合素和体内血管生成抑制剂，抑制血管生成，可用于研究细胞粘附和心血管疾病。