obestatin (human) (trifluoroacetate salt)

Obestatin is a 23 amino acid peptide hormone with a conserved C-terminal glycine residue and amidation site that is formed by cleavage of the ghrelin and obestatin prepropeptide.1It binds to the orphan receptor GPR39 (Kd= 1 nM) and stimulates cAMP production in CHO and HEK293 cells overexpressing human GPR39. Obestatin inhibits contraction of isolated mouse jejunum muscle strips induced by ghrelin .In vivo, obestatin (12.5-1,000 nmol/kg) suppresses food intake in a time- and dose-dependent manner and reduces body weight gain and gastric emptying in mice. Obestatin (0.22 g per animal) also reduces food intake and glucose response without affecting plasma insulin responses in fasted high-fat diet fed mice.2 1.Zhang, J.V., Ren, P.C., Avsian-Kretchmer, O., et al.Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intakeScience310(5750)996-999(2005) 2.Subasinghage, A.P., Green, B.D., Flatt, P.R., et al.Metabolic and structural properties of human obestatin {1-23} and two fragment peptidesPeptides31(9)1697-1705(2010)

Endogenous peptide that suppresses food intake and body weight-gain

Obestatin (human) 是一种由 preproghrelin 经过剪切形成的G蛋白欧联实体39的内源性配体，可以剂量依赖的方式抑制进食，可用于研究肥胖。

Obestatin(rat) TFA 是一个包含23个氨基酸的肽，由Ghrelin基因编码。该化合物能够抑制食欲和空肠收缩，并能减缓体重增加。同时，Obestatin(rat) TFA 作为G 蛋白偶联受体 39 (GPR39) 的内源性配体，发挥抗炎、抗心肌梗塞和抗氧化功能。

Obestatin (rat) acetate 是 G 蛋白偶联受体 39 (GPR39) 的内源性配体。它具有抗炎、抗心肌梗塞和抗氧化特性。 它抑制食物摄入，抑制空肠收缩，并减少体重增加。