nvp-aam077 tetrasodium hydrate

PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) 是一种可口服的NMDA 拮抗剂，具有有效性和选择性。PEAQX tetrasodium hydrate (459836-30-7 free base) 对 hNMDAR 1A/2A 的 IC50 值分别为 270 nM 对hNMDAR 1A/2B 的 IC50 值为29600 nM。

PEAQX, also known as NVP-AAM077; is a competitive antagonist at the NMDA receptor. Although originally described as 100-fold selective for GluN1/GluN2A receptors vs. GluN1/GluN2B receptors, more detailed studies of the Ki of PEAQX revealed it only shows a 5 fold difference in affinity for GluN1/GluN2A vs. GluN1/GluN2B receptors. It is also a potent anticonvulsant in animal tests.

(Rac)-PEAQX 作为NMDA受体的拮抗剂,能够在皮质纹状体切片培养物中促进caspase-3的激活并引发细胞凋亡.

PEAQX (NVP-AAM077) 是 NR2A 高效选择性 NMDA 受体拮抗剂，IC50值为270nM。