nr 7h

Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo.

NR-7h为有效的p38α与p38β选择性降解剂，在T47D和MB-MDA-231细胞中对p38α展示了DC50值分别为24 nM与27.2 nM。