norfluoxetine d5 hydrochloride

Pentoxifylline-D6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM. Pentoxifylline (1,2,and 3 mM)inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5,10,and 20 mg/kg. Formulations containing pentoxifylline have been used in the treatment of intermittent claudication.

Norfluoxetine-D5 hydrochloride是Norfluoxetine Hydrochloride (T21029)的氘代化合物。Norfluoxetine Hydrochloride的CAS号为57226-68-3。Norfluoxetine Hydrochloride是氟西汀的活性代谢物。氟西汀是一种抗抑郁药。

Norfluoxetine-D5 hydrochloride is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9,CYP2C19,and CYP3A. Norfluoxetine inhibits serotonin (5-HT)uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM)and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.