norfluoxetine d5 hcl

Pentoxifylline-D6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM. Pentoxifylline (1,2,and 3 mM)inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5,10,and 20 mg/kg. Formulations containing pentoxifylline have been used in the treatment of intermittent claudication.

Norfluoxetine-D5 hydrochloride is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9,CYP2C19,and CYP3A. Norfluoxetine inhibits serotonin (5-HT)uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM)and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Norfluoxetine-D5 Hcl (Standard) 是 Norfluoxetine-D5 Hcl 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Norfluoxetine-d5 用于通过气相色谱-质谱法或液相色谱-质谱法对诺氟西汀进行定量分析时作为内标物。Norfluoxetine 是抗抑郁药氟西汀的活性代谢产物。它由细胞色素 P450（CYP）亚型 CYP2C9、CYP2C19 和 CYP3A 从氟西汀中生成。