norfluoxetine

Norfluoxetine Hydrochloride (Norfluoxetine HCl) 是氟西汀的活性代谢物。氟西汀是一种抗抑郁药。

Norfluoxetine 是抗抑郁药 Fluoxetine 的活性代谢物，也是血清素吸收的选择性抑制剂。

(S)-Norfluoxetine，Norfluoxetine 的 S 对映体，属于选择性血清素再摄取抑制剂类化合物。此化合物能提升异孕醇酮的浓度，并有助于减少社交孤立小鼠的攻击行为。

(R)-Norfluoxetine 是 Norfluoxetine 的 (R)-对映体，同时也是一种有效的血清素再摄取抑制剂，Ki 值为 13 nM。它被应用于抑郁症研究。

Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.

Norfluoxetine-d5 Hydrochloride 是 Norfluoxetine Hydrochloride 的氘代化合物。Norfluoxetine Hydrochloride 的 CAS 号为 57226-68-3。Norfluoxetine Hydrochloride 是氟西汀的活性代谢物。氟西汀是一种抗抑郁药。

Pentoxifylline-d6 is intended for use as an internal standard for the quantification of pentoxifylline by GC- or LC-MS. Pentoxifylline is a hemorrheologic agent. It increases the deformability of washed isolated human erythrocytes when used at a concentration of 100 µM. Pentoxifylline (1, 2, and 3 mM) inhibits ADP-induced platelet aggregation in isolated human whole blood. It inhibits thrombus formation induced by ADP in a hamster cheek pouch model when administered at doses of 5, 10, and 20 mg kg. Formulations containing pentoxifylline have been used in the treatment of intermittent claudication.

Seproxetine HCl, a more active enantiomer of N-desmethyl metabolite fluoxetine, works by selectively inhibiting the serotonin uptake carrier.