non-peptidic

AS057278 (3-Methylpyrazole-5-carboxylic acid) 是一种 D-氨基酸氧化酶 (DAAO) 抑制剂。

BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1 PD-L 复合物抑制剂，其 IC50为 18 nM，KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1 PD-L 的相互作用，具有抗肿瘤活性。

Embelin (Embelic acid) 是从日本 Ardisia 草药中分离出来的一种非肽类细胞渗透性XIAP 抑制剂，诱导口腔鳞癌细胞自噬和凋亡。它阻断 NF-kappaB 信号通路，从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。在高水平 XIAP 的前列腺癌细胞中抑制细胞生长，诱导凋亡，并激活 caspase-9。

PF-184563 is an effective and selective non-peptidic V1a receptor antagonist.

Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II.

Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.

HA14-1 是一种 Bcl-2 Bcl-xL 拮抗剂，与 Bcl-2 上的特定口袋结合，IC50约为 9 μM。

RP-23618 is a non-peptidic antagonist of RANTES.

LY2811376 是可口服的非肽段β-secretase (BACE1)抑制剂，IC50=239 nM-249 nM，能够降低 Aβ 蛋白的分泌，EC50=300 nM。

CGS 27023A 是一种非肽类强效口服活性基质溶解素抑制剂。

Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.

RXFP3 4 agonist 2 是一种高效的非肽双 RXFP3 4 激动剂，诱导 RXFP3 和 β-arrestin-2 之间的相互作用，可用于研究代谢异常引起的疾病。

Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation.

Y2-Antagonist-2 is a novel, selective, soluble non-​peptidic NPY Y2 receptor antagonist with enhanced CNS exposure.

Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist.

Bag-2 is a Novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist.

CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction.

THX-B为一高效非多肽类p75NTR（神经营养蛋白受体p75）拮抗剂，适用于糖尿病、肾病、神经退行性及炎症性疾病研究。

HIVprotease-IN-1 (compound 1·succinate) 是一种有效的HIV 蛋白酶 (HIV protease) 非肽抑制剂，可用于艾滋病的研究。

HFI-437是一种有效的非肽类胰岛素调节氨肽酶 (IRAP) 抑制剂，Ki为20 nM，同时也是一种认知增强剂。