non-genotoxic

4′-methylacetophenone 是一种香料，普遍存在于食品中的挥发性化合物和某些天然复合物中。

2,5-Dimethyl-3(2H)-furanone (2,5-Dimethyl-2,3-dihydrofuran-3-one) 是一种调味物质，无遗传毒性。

Cyanazine, a triazine herbicide, is utilized for effective control of a diverse range of grass and broadleaf weeds. It has been scientifically validated as non-genotoxic.

CYP2C19-IN-1 是强效的，无遗传毒性的、无肝脏毒性的 CYP2C19 抑制剂。 CYP2C19-IN-1 能够抑制 RNA 依赖的 RNA 聚合酶 (RdRP) (Ki: 6.16 μM)，能够用于研究寨卡病毒 (ZIKV) 感染。

Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.

RK-701 是一种G9a 高选择性且非遗传毒性的抑制剂，IC50值为 23-27 nM。RK-701 选择性的上调 HbF、γ- Globin、BGLT3 的表达，下调 H3K9me2 的表达。RK-701 也对 BCL11A 和 ZBTB7A 有抑制作用。