nms p953

Neomycin (free base) is an antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C. It acts by inhibiting translation during protein synthesis.

NMS-P953 is a JAK2 inhibitor, displaying significant tumor growth inhibition in SET-​2 xenograft tumor model. NMS-P953 has a mechanism of action confirmed in vivo by typical modulation of known biomarkers, and with a favorable pharmacokinetic and safety profile.