nitracrine

Nitracrine is a 1-nitroacridine derivative and is an effective hypoxia-selective agent in vitro and antitumor drugs. Nitracrine suppresses RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine h

Nitracrine dihydrochloride is an acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.

Nitracrine (dihydrochloride hydrate) 抑制RNA合成，通过共价且可逆地结合DNA，在体内形成共价加合物。作为1-nitroacridine衍生物，这种化合物显示出有效的缺氧选择性活性和抗肿瘤作用，同时具有显著的细胞毒性。