nh2 peg7

NH2-PEG7 is a para-aminomethylbenzyloxycarbonyl (PROTAC) linker compound consisting of a polyethylene glycol (PEG) chain. It finds application in the synthesis of the PROTAC PARP1 degrader called iRucaparib-AP6[1].

Boc-NH-PEG7-NH2 是一种基于 PEG 的 PROTAC linker。

Thalidomide-5-PEG7-NH2 hydrochloride 是基于 Thalidomide 而设计，能够招募 CRBN 蛋白的 cereblon 配体。通过 linker，Thalidomide-5-PEG7-NH2 hydrochloride 能与目标蛋白配体相连以形成 PROTAC 分子，如 THAL-SNS-032。

BCN-endo-PEG7-NH2 is an ADC Linker with 7 PEG units and features the lyophilic bidentate macrocyclic ligand endo-BCN, which is utilized in the synthesis of macrocyclic complexes. In click chemistry, endo-BCN reacts with azide-containing molecules to form stable triazoles without the need for catalysts.

(S)-TCO-PEG7-NH2, an ADC linker featuring seven PEG units, leverages its TCO group to facilitate the inverse electron demand Diels-Alder reaction (iEDDA) with Tetrazine-grouped molecules.