multitarget ad inhibitor-1

Multitarget AD inhibitor-1 is a reversible and selective inhibitor of butyrylcholinesterase (BuChE) with IC50 values of 7.22 μM and 1.55 μM for human BuChE (hBuChE) and equine serum BuChE (eqBuChE), respectively. Additionally, it exhibits inhibitory activity towards β-secretase (IC50 value of 41.60 μM), amyloid β aggregation (IC50 value of 3.09 μM), and tau aggregation. As a diphenylpropylamine derivative, Multitarget AD inhibitor-1 holds promise for research pertaining to the multifunctional, disease-modifying treatment of Alzheimer's disease.

SSZ 作为一种多功能抑制剂,对付阿尔茨海默病 (AD) 展现出针对性多重病理机制的作用.它有效靶向乙酰胆碱酯酶 (acetylcholinesterase)、丁酰胆碱酯酶 (butyrylcholinesterase)、β-位淀粉样蛋白前体裂解酶 1 (BACE1) 和 γ-分泌酶 (γ-secretase),能够在小鼠模型中延缓阿尔茨海默病的进程,并发挥神经保护作用.