mts 1

ADAMTS7-IN-1（Compound 3a）, 表现为一种高效的选择性ADAMTS7抑制剂，Ki值仅为9 nM。该化合物主要用于动脉粥样硬化的相关研究。

Irinotecan (CPT-11) 是喜树碱的衍生物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂。Irinotecan 通过与 Topo I 复合物结合来阻止 DNA 链的重新连接，并导致双链 DNA 断裂和细胞死亡，具有抗肿瘤活性。

HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively[1]. HCoV-229E-IN-1 (compound 5h) (0.01-100 μM) fully suppresses the capacity of HCoV-229E replication in a dose-dependent manner[1].HCoV-229E-IN-1 (12 μM) fully prevented the formation of dsRNA intermediates of CoV RNA synthesis[1]. [1]. Stevaert A, et, al. Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. J Med Chem. 2021 May 13;64(9):5632-5644.

STAT3-IN-24，cell-permeable (PpYLKTK-mts) 是STAT3多肽抑制剂。STAT3-IN-24通过阻止STAT3向Jak2的募集和Y705的磷酸化，防止STAT3的二聚化和核转位。