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S100A4 Protein, Human, Recombinant (His)

产品编号 TMPY-03934

别名: 42A, 18A2, PEL98, CAPL, MTS1, S100 calcium binding protein A4, FSP1, P9KA

S100A4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.6 kDa and the accession number is P26447.

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S100A4 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	S100A4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 12.6 kDa and the accession number is P26447.

种属	Human
表达系统	E. coli
标签	C-His
蛋白编号	P26447
别名	42A, 18A2, PEL98, CAPL, MTS1, S100 calcium binding protein A4, FSP1, P9KA
蛋白构建	The Human S100A4 (NP_002952.1) (Met1-Lys101)
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	12.6 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	S100A4, also known as metastasis-associated protein Mtsl, belongs to the family of small calcium-binding S100 proteins containing two EF-hand calcium-binding motifs. In humans at least 20 S100 family members that are distributed tissue specifically have been identified, and are involved in a number of cellular processes as transducers of calcium signal. S100A4 is a symmetric homodimer, and undergoes a relatively large conformational change upon the typical EF-hand binding calcium, which is necessary for S100A4 to interact with its protein targets and generate biological effects. It can bind the already known targets p53, F-actin, liprin β, myosin heavy chain II, and prevent their phosphorylation and multimerization. It has been demonstrated that S100A4 is directly involved in tumor metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation, and appears to be a metastasis factor and a molecular marker for clinical prognosis. Multiple alternatively spliced variants encoding the same protein have been identified.

参考文献

1. Ambartsumian N. et al., 1995, Gene. 159: 125-30. 2. Marenholz I. et al., 2004, Biochem Biophys Res Commun. 322: 1111-22. 3. Helfman DM. et al., 2005, Br J Cancer. 92: 1955-8. 4. Saleem M. et al., 2006, Proc Natl Acad Sci. 103: 14825-30. 5. Boye K. et al., 2008, Int J Cancer. 123: 1301-10. 6. Garrett SC. et al., 2006, J Biol Chem. 281: 677-80. 7. Kriajevska M. et al., 2002, J Biol Chem. 277: 5299-335.

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Keywords

S100A4 Protein, Human, Recombinant (His) 42A 18A2 MTS-1 PEL 98 PEL98 CAPL MTS1 S100 calcium binding protein A4 MTS 1 FSP1 FSP-1 PEL-98 FSP 1 P9KA recombinant recombinant-proteins proteins protein

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