ms 33

MS33 is a highly effective degrader of the WDR5 protein, exhibiting Kd values of 870 nM and 120 nM for VCB and WDR5, respectively. It induces degradation of WDR5 through an E3 ligase VHL-mediated and proteasome-dependent mechanism. MS33 holds promise for furthering research in the field of acute myeloid leukemia.

BMS-332为DGKα ζ脂激酶的双抑制剂，其对DGKα的IC50为0.005 μM，对DGKζ的IC50为0.001 μM。

BMS-337197 是一种 IMPDH 抑制剂。