mrs2905

Potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM). Exhibits >2000-fold selectivity over P2Y6. Das et al (2010) Human P2Y14 receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups J.Med.Chem. 53 471 PMID:19902968 |Lazarowski et al (2015) UDP-sugars as extracellular signaling molecules: cellular and physiologic consequences of P2Y14 receptor activation. Mol.Pharmacol. 88 151 PMID:25829059

MRS2905 (α,β-Methylene-2-thio-UDP) trisodium 是一种选择性P2Y14R激动剂，EC50为0.92 nM。MRS2905 trisodium 对UDP激活的P2Y6受体及其他P2Y受体无活性。