mm-401

MM-401 is a specific inhibitor of histone H3K4 methyltransferase MLL1 activity that acts by reprogramming mouse epiblast stem cells to naive pluripotency.

MM-401 (TFA) 是一种针对MLL1 H3K4甲基转移酶的抑制剂，通过阻断MLL1与WDR5的相互作用，有效抑制MLL1活性，其IC50值为0.32 µM。此化合物能够诱导细胞周期停滞、凋亡及分化，主要用于MLL白血病的研究。