ml-115

ML115 是一种有效且选择性的转录 3 (STAT3) 激活剂，abn EC50 为 2.0 nM，对相关的 STAT1 和 NFκB 抗靶点无活性。

1-Heptadecanoyl-rac-glycerol is a monoacylglycerol that contains heptadecanoic acid at the sn-1 position. It is active against the bacteria E. aerogens, E. cloacae, P. mirabilis, and S. faecalis (MIC = 78 μg ml for all).1 1-Heptadecanoyl-rac-glycerol has been found in T. africana, I. sonorae, and wheat bran.1,2,3 |1. Kuete, V., Metuno, R., Ngameni, B., et al. Antimicrobial activity of the methanolic extracts and compounds from Treculia africana and Treculia acuminata (Moraceae). S. Afr. J. Bot. 74(1), 111-115 (2008).|2. Fernández-Galicia, E., Calada, F., Roman-Romos, R., et al. Monoglycerides and fatty acids from Ibervillea sonorae root: Isolation and hypoglycemic activity. Planta Med. 73(3), 236-240 (2007).|3. Prinsen, P., Gutiérrez, A., Faulds, C.B., et al. Comprehensive study of valuable lipophilic phytochemicals in wheat bran. J. Agric. Food Chem. 62(7), 1664-1673 (2014).

Arcopilin A（compound Arcopilin A(1)）属于抗菌化合物，虽然对真菌病原体和革兰氏阳性菌的抑制力较弱，其对KB-3-1和L929细胞的IC50分别为8.9 μg mL和14 μg mL。此外，Arcopilin A能有效破坏金黄色葡萄球菌预先形成的生物膜，并显著增强庆大霉素(GM)和万古霉素(Vac)的活性，分别提高至115倍和31倍。