ml 277

ML277 (CID-53347902) 是一种有效的，选择性K(v)7.1 钾离子通道激动剂，EC50为270nM。

BML-277 (C 3742) 是一种选择性的检测点激酶 2 抑制剂，IC50为 15 nM。

BML277 Acid is a metabolite of BML277 which is a selective checkpoint kinase 2 inhibitor.

P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer’s disease[1]. P11149 is a GAL analog that is rapidly hydrolyzed in vivo to yield the potent AChE inhibitor, 6-DMG[1].P11149 exhibits greater s.c. bioavailability than p.o. [1].Oral P11149 in mice produces Sal, Lac and tremors at doses similar to those in rats, whereas 6-DMG, P1 1012 and GAL produces Sal and Lac at doses lower than those in rats[1].P11149 exhibits T1 2(el) of 2.4 h and Cmax of 585 ng mL in rat plasma[1]. [1]. G M Bores, et al. Pharmacological evaluation of novel Alzheimer’s disease therapeutics: acetylcholinesterase inhibitors related to galanthamine. J Pharmacol Exp Ther. 1996 May;277(2):728-38.