methyltetrazine-acid

Methyltetrazine-acid is an alkyl chain-derived linker employed for PROTAC synthesis[1].

Methyltetrazine-PEG8-acid is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Methyltetrazine-PEG13-acid is a PEGylated linker derived from PEG that serves as a valuable component in the production of PROTACs, a class of compounds known for their targeted protein degradation properties[1].

Methyltetrazine-PEG25-acid is a PEG-derived PROTAC linker utilized for the synthesis of PROTACs[1].

Methyltetrazine-PEG4-acid is a PEG-based linker utilized in the synthesis of PROTACs[1].

Methyltetrazine-amido-N-bis(PEG4-acid) 为含甲基四氮基的高效点击化学试剂.该化合物含 Tetrazine 基团和双羧酸端基,属于 PEG 衍生物,可在不需要 Cu 催化及高温条件下与含 TCO 的生物分子进行反应,通过 Diels-Alder 环加成反应(即逆电子需求 Diels-Alder 反应,iEDDA)迅速形成稳定共价键.此种反应速度快,选择性高.另外,末端羧酸可在激活剂(如 EDC 或 HATU)存在下与伯胺反应,形成酰胺键.PEG 连接增强了其在水中的溶解性.本品为试剂级,仅限研究使用.