memory deficiency

Aleplasinin (PAZ 417) 是纤溶酶原激活物抑制剂 1 (PAI-1) 的选择性和口服活性抑制剂，是纤溶系统的关键负调节剂。 Aleplasinin 可用于阿尔茨海默病研究。

胆碱是一种必需营养素，对肝脏、神经、血液和骨骼肌的稳态起重要作用。它是膜磷脂如卵磷脂合成的前体，有助于细胞信号传导和跨膜运输，也是神经递质乙酰胆碱的前体。胆碱在肝脏脂质运输中必不可少。围产期给予胆碱(18.8 mg/kg)可改善酒精暴露对大鼠认知的影响。胆碱(13 mg/animal per day)改进了Rett综合征小鼠模型的运动协调和行为缺陷，并且在饮用水中以5 ppm浓度给予时，改善了铁缺乏引起的识别记忆问题。胆碱摄入不足与肌肉消耗呈正相关，在饮食中添加胆碱(1,000 mg/kg)可增加肉鸡腿部和胸部肌肉蛋白含量。

BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1].

Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and