meiqx

MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3

4,7,8-TriMeIQx 是咪唑喹啉类化合物，具有致突变性。

7,8-DimeIQX 是一种杂环芳香胺，具有致突变性和致癌性。

4,8-DiMeIQx 是一种杂环芳香胺，具有致突变性和致癌性。