mcn-4853

Topiramate (RWJ 17021) 是一种GluR5受体拮抗剂，可通过增强GABAergic 活性，抑制kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制碳酸酐酶来产生抗癫痫作用，用于治疗部分性和全身性癫痫发作。

Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor.

Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3]

Topiramate-13C6 (McN 4853-13C6) 是具备13C 标记的Topiramate。Topiramate (McN 4853) 是一种广泛应用的抗癫痫药物，同时也是GluR5受体拮抗剂。其抗癫痫功效通过多种方式实现，包括增强GABAergic活性、抑制kainate/AMPA受体、电压依赖性钠和钙通道抑制、增加钾电导和抑制carbonic anhydrase。