mc-val-cit-pab-mmaf

MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavable linker, MC-Val-Cit-PAB.

ADC Control Human IgG1-vcMMAF 是人源单克隆抗体，作为 ADC human IgG1-vcMMAF 同型对照，具有抑制微管蛋白聚合的功能。此化合物的抗体部分是 Human IgG1 kappa, Isotype Control，而 ADC 毒性分子和 linker 则是 MC-Val-Cit-PAB-MMAF (vcMMAF)。