maresin 2

Maresin 2 (3R,14S-diHDHA) 是一种专门的促消退脂质介质 （SPM），具有抗炎镇痛活性，促进粘膜修复，可减少酵母聚糖腹膜炎中的中性粒细胞募集。

Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 and PGF2α in the exudate.

Maresin 1 是由巨噬细胞 (MΦ) 生物合成的小分子化合物，具有显著的抗炎活性，可通过抑制中性粒细胞粘附和降低促炎细胞因子水平来减轻LPS诱导的小鼠肺损伤，可以刺激胞内 Ca2+ 产生和分泌。