maprotiline-d3 hydrochloride

Maprotiline-D3 hydrochloride is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline hydrochloride (T0172) is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET)and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT)receptor subtype 5-HT2A,as well as histamine H1,muscarinic acetylcholine,α1-adrenergic,and dopamine D2 receptors. In vivo,maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.

Maprotiline-D3 Hydrochloride (Standard) 是 Maprotiline-D3 Hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Maprotiline-d3 用于通过气相色谱-质谱法或液相色谱-质谱法对Maprotiline进行定量分析时作为内标物。Maprotiline是一种三环类抗抑郁药。

Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin.