mal-peg1-boc

Mal-PEG1-Boc is a alkyl ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal是一种具有特定结构修饰的氨基酸：其C端连接马来酰亚胺，α-胺位带有Boc保护基，ε-胺位连接酰胺-PEG1-叔丁基酯。马来酰亚胺是硫醇反应性共价基团，用于结合半胱氨酸残基，而Boc和叔丁基酯保护基可在后期进行脱保护以支持进一步反应。