m122

M122 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.

M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.

ZZM-1220是一种针对组蛋白赖氨酸甲基转移酶G9a GLP的共价抑制剂，IC50值分别为458 nM和924 nM。该化合物能有效抑制H3K9me2在细胞中的作用，从而显著促进三阴性乳腺癌(TNBC)细胞的凋亡(apoptosis)，同时在G2 M期阻断细胞周期的进程。