m-peg12-thiol

m-PEG12-Thiol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

M-PEG12-Mal is a PEG derivative containing a maleimide group. The hydrophilic PEG spacer increases solubility in aqueous media. The maleimide group could form a covalent bond with a thiol group , enabling the further connection of biomolecule with a thiol