m-199

M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.

Pyrazosulfuron-ethyl (Standard) 是 Pyrazosulfuron-ethyl 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pyrazosulfuron-ethyl（吡嘧磺隆）是一种用于控制水稻中阔叶杂草、草和莎草的磺酰脲类除草剂，通过抑制ALS(acetolactate synthase)起作用。

Pyrene-d10 (Standard) 是 Pyrene-d10 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pyrene-d10 是 Pyrene 的氘代化合物。Pyrene 的 CAS 号为 129-00-0。

Pyribencarb (Standard) 是 Pyribencarb 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pyribencarb，一种苯甲酰胺类杀菌剂，针对多种植物病原真菌展现出广谱活性。作为细胞色素b的强效Qo抑制剂，Pyribencarb 对灰霉病菌（Botrytis cinerea）和菌核病菌（Sclerotinia sclerotiorum）特别有效。

Pyributicarb (Standard) 是 Pyributicarb 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pyributicarb (TSH-888) 是氨基甲酸酯型除草剂，能够有效激活CYP3A4基因及人类孕烷 X 受体。

Pyridate (Standard) is the standard substance of Pyridate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyridate is mainly used as a selective post seedling herbicide.

Astragaloside II (Standard) 是 Astragaloside II 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。

Pyridoxal hydrochloride (Standard) 是 Pyridoxal hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pyridoxal hydrochloride 是内源性代谢产物的一种。

Astragaloside III (Standard) 是 Astragaloside III 的标准品。适用于定量分析、质量控制及生化实验等相关研究。Astragaloside III 是一种分离自黄芪中的一种天然产物。

Pyridoxine hydrochloride (Standard) 是 Pyridoxine hydrochloride 的标准品，适用于定量分析、质量控制及生化实验等相关研究。Pyridoxine hydrochloride (Vitamin B6) 是一种吡啶衍生物。在于阿尔茨海默病细胞模型中，通过 Nrf-2/HO-1 途径发挥抗氧化作用。

Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (ORG1) that induces calcium accumulation in cells overexpressing OGR1 (EC50= ~35 nM).4Levels of D-erythrolysosphingomyelin are increased in skin isolated from patients with atopic dermatitis, as well as postmortem brain from patients with Niemann-Pick disease type A, but not type B.2,5L-threolysosphingomyelin is also an S1P1-3agonist (EC50s = 19.3, 131.8, and 313.3 nM, respectively).3This product is a mixture of D-erythroand L-threolysosphingomyelin. [Matreya, LLC. Catalog No. 1321] 1.Ito, M., Kurita, T., and Kita, K.A novel enzyme that cleaves the N-acyl linkage of ceramides in various glycosphingolipids as well as sphingomyelin to produce their lyso formsJ. Biol. Chem.270(41)24370-24374(1995) 2.Nixon, G.F., Mathieson, F.A., and Hunter, I.The multi-functional role of sphingosylphosphorylcholineProg. Lipid Res.47(1)62-75(2008) 3.Im, D.-S., Clemens, J., Macdonald, T.L., et al.Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): Structure-activity relationship of sphingosine1-phosphate receptorsBiochemistry40(46)14053-14060(2001) 4.Meyer zu Heringdorf, D., Himmel, H.M., and Jakobs, K.H.Sphingosylphosphorylcholine-biological functions and mechanisms of actionBiochim. Biophys. Acta1582(1-3)178-189(2002) 5.Rodriguez-Lafrasse, C., and Vanier, M.T.Sphingosylphosphorylcholine in Niemann-Pick disease brain: Accumulation in type A but not in type BNeurochem. Res.24(2)199-205(1999)