loxin3

LOX-IN-3, an orally active inhibitor of lysyl oxidase (LOX), holds potential application in the fields of fibrosis, cancer, and angiogenesis research[1].

LOX-IN-3 dihydrochloride 是口服有效的赖氨酰氧化酶抑制剂，在纤维化，癌症和/或血管生成方面有研究价值。

COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows promise for the investigation of inflammatory diseases [1].

LOX-IN-3 dihydrochloride monohydrate (Compound 33) is a lysyl oxidase (LOX) inhibitor with oral activity. It is specifically designed for research purposes in the areas of fibrosis, cancer, and angiogenesis [1].

COX-2/15-LOX-IN-3 (compound 5k) 为COX-2/15-LOX的一种双重抑制剂，具有分别为0.075 μM和1.97 μM的IC50值。该化合物能显著抑制LPS诱导的细胞产生促炎细胞因子（IL-6, ROS和NO），表明其具备显著的抗炎活性。

Caloxin 3A1是生物活性肽，属于caloxins系列，特指抑制外质膜(Plasma membrane, PM) Ca2+泵的化合物。具体作用通过抑制质膜钙泵(PMCA)并保持对肌浆网Ca2+泵无影响；同时，该肽不干预ATP合成酰基磷酸中间产物的形成。