lolcde

LolCDE-IN-1 是一种有抗菌活性的LolCDE 复合物抑制。

LolCDE-IN-2 是一种有效的 Lol 蛋白(LolCDE)抑制剂。LolCDE-IN-2 具有抗菌活性，抑制大肠杆菌 MG1655 的 MIC 值为 2 μg ml。

LolCDE-IN-4 (Compound 1) 显示出对革兰氏阴性细菌Escherichia coli (MIC为 0.25-32 µg ml) 和 Haemophilus influenzae具有抗菌活性，其机制是通过抑制LolCDE复合物以及中断内膜脂蛋白的释放。

G0507 is a pyrrolopyrimidinedione compound that serves as a potent inhibitor of Escherichia coli growth, effectively inducing the extracytoplasmic σE stress response. It acts as a valuable chemical probe, specifically designed to dissect lipoprotein trafficking in Gram-negative bacteria. Notably, G0507 demonstrates strong inhibitory activity against the LolCDE ABC Transporter.