leuams r enantiomer

Leu-AMS R enantiomer 是 Leu-AMS 的 R 对映体。 Leu-AMS 是一种有效的亮氨酰-tRNA 合成酶 (LRS) 抑制剂，可抑制细菌的生长。

Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.